Gary D Luker Selected Research

Chemokine CXCL12

1/2018	Three-dimensional tumor model mimics stromal - breast cancer cells signaling.
1/2017	The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue.
2/2015	Surface-templated hydrogel patterns prompt matrix-dependent migration of breast cancer cells towards chemokine-secreting cells.
1/2014	CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7.
11/2013	Allosteric peptide regulators of chemokine receptors CXCR4 and CXCR7.
1/2013	Imaging CXCL12-CXCR4 signaling in ovarian cancer therapy.
3/2012	Secreted CXCL12 (SDF-1) forms dimers under physiological conditions.
12/2011	Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4.
11/2010	Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells.
10/2009	Imaging ligand-dependent activation of CXCR7.

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Gary D Luker Research Topics

Disease

73	Neoplasms (Cancer) 02/2022 - 05/2002
28	Breast Neoplasms (Breast Cancer) 01/2022 - 12/2004
25	Neoplasm Metastasis (Metastasis) 01/2020 - 12/2004
9	Triple Negative Breast Neoplasms 01/2022 - 07/2015
8	Infections 09/2008 - 12/2002
4	Virus Diseases (Viral Diseases) 04/2010 - 12/2002
3	Carcinogenesis 02/2022 - 01/2016
3	Disease Progression 01/2022 - 01/2003
3	Glioblastoma (Glioblastoma Multiforme) 12/2021 - 01/2015
3	Colorectal Neoplasms (Colorectal Cancer) 12/2020 - 11/2017
3	Melanoma (Melanoma, Malignant) 12/2020 - 01/2011
3	Ovarian Neoplasms (Ovarian Cancer) 01/2013 - 12/2011
3	Vaccinia 09/2008 - 10/2005
2	Prostatic Neoplasms (Prostate Cancer) 11/2019 - 01/2018
2	Atherosclerosis 11/2013 - 03/2012
2	Lung Neoplasms (Lung Cancer) 01/2011 - 10/2007
2	Herpes Simplex 05/2003 - 04/2002
1	Primary Myelofibrosis (Myelosclerosis) 02/2022
1	Metaplasia 12/2020
1	Stomach Neoplasms (Stomach Cancer) 12/2020
1	Gastritis 12/2020
1	Neuroblastoma 01/2020
1	Autoimmune Diseases (Autoimmune Disease) 01/2019

Drug/Important Bio-Agent (IBA)

14	Pharmaceutical PreparationsIBA 12/2020 - 01/2003
11	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2002
10	Chemokine CXCL12IBA 01/2018 - 10/2009
8	Phosphotransferases (Kinase)IBA 02/2022 - 01/2019
8	LuciferasesIBA 01/2022 - 12/2002
8	Biomarkers (Surrogate Marker)IBA 12/2021 - 07/2008
8	Chemokine ReceptorsIBA 01/2020 - 12/2004
7	ChemokinesIBA 01/2019 - 10/2007
7	CXCR4 Receptors (CXCR4 Receptor)IBA 01/2018 - 06/2009
7	Firefly LuciferasesIBA 12/2011 - 12/2002
6	LigandsIBA 02/2021 - 12/2004
6	CollagenIBA 01/2021 - 07/2014
6	Biological ProductsIBA 01/2020 - 11/2016
5	HydrogelsIBA 01/2022 - 02/2015
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 02/2022 - 03/2019
4	Protein Isoforms (Isoforms)IBA 01/2017 - 05/2014
3	EnzymesIBA 01/2022 - 06/2008
3	beta-Arrestin 1IBA 01/2022 - 03/2012
3	RNA (Ribonucleic Acid)IBA 01/2021 - 05/2014
3	plerixafor FDA Link 01/2013 - 12/2004
3	Tumor Viral Antigens (Large T Antigen)IBA 10/2008 - 05/2002
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022 - 12/2019
2	Estrogen ReceptorsIBA 01/2022 - 01/2020
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 02/2021 - 01/2019
2	AlginatesIBA 01/2021 - 01/2018
2	Mitogen-Activated Protein KinasesIBA 12/2020 - 01/2020
2	Protein Kinases (Protein Kinase)IBA 01/2020 - 01/2010
2	PhytochemicalsIBA 01/2020 - 07/2015
2	Extracellular Matrix ProteinsIBA 01/2020 - 11/2016
2	NAD (NADH)IBA 01/2020 - 01/2019
2	Caspase 3 (Caspase-3)IBA 06/2018 - 12/2017
2	Monoclonal AntibodiesIBA 10/2016 - 01/2016
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2015 - 07/2003
2	Antiviral Agents (Antivirals)IBA 06/2008 - 10/2003
2	InterferonsIBA 10/2005 - 10/2003
2	Thymidine KinaseIBA 05/2003 - 04/2002
1	FibrinIBA 01/2022
1	Estrogens (Estrogen)FDA Link 01/2022
1	EmulsionsIBA 01/2022
1	Contrast MediaIBA 01/2022
1	IronIBA 01/2022
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2022
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2022
1	Pyruvate KinaseIBA 01/2022
1	ErbB Receptors (EGF Receptor)IBA 02/2021
1	tyrosine receptor (receptor, tyrosine)IBA 02/2021
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2021
1	Fibronectins (Fibronectin)IBA 01/2021
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2021
1	spasmolytic polypeptideIBA 12/2020
1	InflammasomesIBA 12/2020
1	QuercetinIBA 01/2020
1	fisetinIBA 01/2020
1	MK 2206IBA 01/2020
1	Leflunomide (Arava)FDA LinkGeneric 01/2020
1	Thioredoxin-Disulfide ReductaseIBA 01/2020
1	Tamoxifen FDA LinkGeneric 01/2020
1	Bovine Serum AlbuminIBA 12/2019
1	Lactic Acid (Lactate)FDA LinkGeneric 11/2019
1	MTOR InhibitorsIBA 03/2019
1	MitogensIBA 03/2019
1	GelsIBA 01/2019
1	NanogelsIBA 01/2019
1	Plasminogen Activator Inhibitor 1IBA 01/2019
1	Fibrillar CollagensIBA 01/2019
1	Collagen Type I (Type I Collagen)IBA 01/2019
1	nanolucIBA 01/2018
1	Biocompatible Materials (Biomaterials)IBA 01/2018
1	Tyrosine Kinase InhibitorsIBA 01/2018
1	Technetium Tc 99m MedronateIBA 01/2018
1	cabozantinibIBA 01/2018
1	Immune Checkpoint InhibitorsIBA 11/2017

Therapy/Procedure

35	Therapeutics 02/2022 - 12/2002
7	Drug Therapy (Chemotherapy) 12/2020 - 07/2015
2	Precision Medicine 01/2020 - 01/2018
2	Lab-On-A-Chip Devices 12/2019 - 06/2009
1	Castration 01/2018